Furthermore, experiments were conducted by applying a monochromatic frequency to the beam and detecting transmitted vibrations at the beam and SMR systems. The transfer matrix method establishes the force-displacement relationship between each unit cell. In the analytical method, a single unit cell comprises an Euler Bernoulli beam attached by a lumped mass and a spring-mass resonator (SMR) system.

Both analytical and experimental investigations are carried out to compare the transmittance of the dynamic displacement response of the entire system. This paper investigates the vibration suppression characteristics of a base-excited cantilever beam having a series of lumped masses and spring-mass resonator systems. With this proof-of-concept in hand, the system can be easily customized to produce other radiopharmaceuticals.ĭynamic vibration absorbers are of utmost importance in civil and mechanical engineering applications however, their intricate mechanisms are always challenging for practical realization. radiofluorination, dilution, SPE-trapping, deprotection, and SPE-elution.

This system was designed to perform the typical functions and operations required in radiotracer production i.e. As a proof of concept, we conceptualized, developed, and tested a custom flow system that can be used to synthesize 2-fluoro-2-desoxy-d-glucose (FDG), the most commonly used PET-tracer. Our compact 3D-printed system meets the needs of many applications in flow chemistry research as well as educational requirements for universities. Having a compact and individually adjustable system is thus beneficial, with 3D printing technology offering the solution. In addition, space in research laboratories is usually limited and commercially available flow systems can be very bulky. To implement accessible flow chemistry at research facilities, the systems must be made affordable. Such systems stand to benefit the emerging academic pharmaceutical field by providing the experience and availability of reliable and affordable solutions. This high price of entry makes such technology prohibitively expensive for many research groups. Commercially available flow systems can be very expensive with equipment starting at, but often greatly exceeding, 10,000 €. The entire system can be built for around 500 €. In this work, we introduce a low-cost open-source flow system that includes a dual syringe pump with implemented pressure sensor and back pressure regulator.

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